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. 2014 Aug 23;11:148. doi: 10.1186/s12974-014-0148-9

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© Yang et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CNPase knockdown does not affect the nuclear translocation of NF-κB in activated BV-2 microglial cells. (A) Western blot shows the expression of NF-κB (65 kDa) and Lamin A (74 kDa) in nuclear protein isolated from the various groups. (B) Expression of nuclear NF-κB protein was significantly increased in BV-2 cells exposed to lipopolysaccharide (LPS) for 3 hours, and this increase has no significance between control small interfering RNA (siRNA) and CNPase siRNA tranfected BV-2 cells. Data are presented as mean ± SD (n = 3), ***P < 0.001; ns, no significant difference. CNPase, 2′,3′-cyclic nucleotide 3′-phosphodiesterase.