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. Author manuscript; available in PMC: 2014 Nov 25.
Published in final edited form as: Annu Rev Immunol. 2013 Jan 3;31:413–441. doi: 10.1146/annurev-immunol-032712-095951

Figure 2.

Figure 2

Regulation of NKG2D ligands at different stages of ligand biogenesis (gene→mRNA→protein, depicted in green boxes) and degradation (orange boxes). The regulatory signals and pathways that regulate NKG2D ligands are depicted, as well as whether they act transcriptionally, by stabilizing or targeting ligand mRNAs, by stabilizing ligand proteins, or by cleavage of the ligand from the cell surface. The blue text boxes specify stress or pathological states, whereas the green text boxes specify different mediators, with the affected ligands indicated parenthetically in black. 1Proliferative signals regulate mouse Raet1 and human RAET1/ULBP and possibly MICA/B expression, but the role of E2F was demonstrated specifically in the case of Raet1 genes. 2The activated DNA damage response induces mouse Raet1 and Mult1 expression as well as human RAET1/ULBP and possibly MICA/B expression, but the role of mRNA stabilization was demonstrated specifically for Raet1 transcripts. See the text for additional details.