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. 2014 Nov 25;9(11):e113654. doi: 10.1371/journal.pone.0113654

Table 3. Descriptions of placebo found on the selected webpages of some organizations.

Organization Webpages Descriptions of placebo
ClinicalTrials.gov http://clinicaltrials.gov/ct2/about-studies/glossary#P A substance that does not contain active ingredients and is made to be physically indistinguishable (that is, it looks and tastes identical) from the actual drug being studied.
ICH guidelines: E10: Choice of Control Group and Related Issues in Clinical Trials (Section 2.1) http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E10/Step4/E10_Guideline.pdf A "dummy" treatment that appears as identical as possible to the test treatment with respect to physical characteristics such as colour, weight, taste and smell, but that does not contain the test drug.
EU Clinical Trials Register https://www.clinicaltrialsregister.eu/doc/EU_Clinical_Trials_Register_Glossary.pdf A placebo is a control substance (a dummy treatment) that is given to people taking part in a clinical trial.
Medline Plus Medical Library http://www.merriam-webster.com/medlineplus/placebo 1: A usually pharmacologically inert preparation prescribed more for the mental relief of the patient than for its actual effect on a disorder. 2: An inert or innocuous substance used especially in controlled experiments testing the efficacy of another substance, such as a drug.
National Institutes of Health (NIH) http://www.nih.gov/health/clinicaltrials/glossary.htm A placebo is a pill or liquid that looks like the new treatment but does not have any treatment value from active ingredients.
NIH-Clinical Center http://www.cc.nih.gov/participate/faqaboutcs.shtml Placebos are harmless, inactive substances made to look like the real medicine used in the clinical trial.
NIH-National Heart lung and Blood Institute (NHLBI-NIH) http://www.nhlbi.nih.gov/childrenandclinicalstudies/terms.php#Placebo Placebo is a pill, liquid or powder that has no active medicine in it. It's a fake.
National Library of Medicine – Medical Subject Headings (MeSH) http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?mode=&index=10448&field=all&HM=&II=&PA=&form=&input= Any dummy medication or treatment.
World Health Organization (WHO) http://whqlibdoc.who.int/publications/2009/9789241547727_eng.pdf In the context of research, a placebo is a substance or procedure which patients accept as a medicine or therapy, but which actually has no specific therapeutic activity for their conditions.