Table 4. Familial risk (sibling/parent history) of concordant kidney failure in males and females by age diagnosis.
| Males | Females | All | ||||||||||
| Age at diagnosis (years) | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | |||
| Acute kidney failure | ||||||||||||
| <10 | 4 | 16.78 | 4.36 | 43.39 | 2 | 10.88 | 1.03 | 40.02 | 6 | 14.21 | 5.11 | 31.14 |
| 10–19 | 0 | 0 | 0 | |||||||||
| 20–29 | 6 | 2.00 | 0.72 | 4.37 | 5 | 3.70 | 1.17 | 8.70 | 11 | 2.52 | 1.25 | 4.53 |
| 30–39 | 11 | 1.43 | 0.71 | 2.57 | 2 | 0.61 | 0.06 | 2.24 | 13 | 1.18 | 0.63 | 2.03 |
| 40–49 | 22 | 1.23 | 0.77 | 1.87 | 14 | 1.57 | 0.86 | 2.64 | 36 | 1.34 | 0.94 | 1.86 |
| 50–59 | 52 | 1.35 | 1.01 | 1.78 | 21 | 0.84 | 0.52 | 1.28 | 73 | 1.15 | 0.90 | 1.45 |
| > = 60 | 58 | 0.80 | 0.61 | 1.03 | 40 | 0.99 | 0.71 | 1.35 | 98 | 0.87 | 0.70 | 1.06 |
| All | 153 | 1.09 | 0.92 | 1.27 | 84 | 1.05 | 0.84 | 1.30 | 237 | 1.08 | 0.94 | 1.22 |
| Chronic kidney failure | ||||||||||||
| <10 | 2 | 3.92 | 0.37 | 14.41 | 0 | 2 | 2.09 | 0.20 | 7.70 | |||
| 10–19 | 16 | 6.94 | 3.96 | 11.30 | 11 | 5.60 | 2.78 | 10.06 | 27 | 6.33 | 4.16 | 9.22 |
| 20–29 | 41 | 4.87 | 3.49 | 6.61 | 33 | 4.35 | 2.99 | 6.12 | 74 | 4.62 | 3.63 | 5.81 |
| 30–39 | 91 | 2.36 | 1.90 | 2.90 | 43 | 1.76 | 1.27 | 2.37 | 134 | 2.13 | 1.78 | 2.52 |
| 40–49 | 135 | 2.08 | 1.75 | 2.47 | 75 | 2.11 | 1.66 | 2.65 | 210 | 2.09 | 1.82 | 2.40 |
| 50–59 | 187 | 1.86 | 1.60 | 2.14 | 92 | 1.74 | 1.40 | 2.14 | 279 | 1.82 | 1.61 | 2.04 |
| > = 60 | 245 | 1.81 | 1.59 | 2.05 | 141 | 1.81 | 1.52 | 2.14 | 386 | 1.81 | 1.63 | 2.00 |
| All | 717 | 2.04 | 1.90 | 2.20 | 395 | 1.97 | 1.78 | 2.17 | 1112 | 2.02 | 1.90 | 2.14 |
| Unspecified kidney failure | ||||||||||||
| <10 | 0 | 0 | 0 | |||||||||
| 10–19 | 0 | 0 | 0 | |||||||||
| 20–29 | 1 | 2.39 | 0.00 | 13.67 | 1 | 4.41 | 0.00 | 25.26 | 2 | 3.10 | 0.29 | 11.38 |
| 30–39 | 6 | 2.80 | 1.01 | 6.12 | 1 | 1.04 | 0.00 | 5.95 | 7 | 2.25 | 0.89 | 4.66 |
| 40–49 | 2 | 0.58 | 0.05 | 2.12 | 4 | 1.62 | 0.42 | 4.18 | 6 | 1.01 | 0.36 | 2.21 |
| 50–59 | 8 | 1.04 | 0.45 | 2.07 | 4 | 1.18 | 0.31 | 3.05 | 12 | 1.09 | 0.56 | 1.90 |
| > = 60 | 16 | 1.13 | 0.64 | 1.83 | 11 | 1.35 | 0.67 | 2.43 | 27 | 1.21 | 0.80 | 1.76 |
| All | 33 | 1.18 | 0.81 | 1.65 | 21 | 1.38 | 0.85 | 2.11 | 54 | 1.25 | 0.94 | 1.63 |
| All kidney failure | ||||||||||||
| <10 | 6 | 3.28 | 1.18 | 7.19 | 6 | 3.52 | 1.27 | 7.71 | 12 | 3.40 | 1.75 | 5.95 |
| 10–19 | 23 | 3.43 | 2.17 | 5.15 | 24 | 4.02 | 2.57 | 5.98 | 47 | 3.70 | 2.72 | 4.93 |
| 20–29 | 72 | 2.53 | 1.98 | 3.18 | 56 | 2.83 | 2.14 | 3.68 | 128 | 2.65 | 2.21 | 3.15 |
| 30–39 | 180 | 1.74 | 1.49 | 2.01 | 87 | 1.47 | 1.18 | 1.82 | 267 | 1.64 | 1.45 | 1.85 |
| 40–49 | 290 | 1.45 | 1.29 | 1.63 | 178 | 1.58 | 1.36 | 1.83 | 468 | 1.50 | 1.37 | 1.64 |
| 50–59 | 515 | 1.41 | 1.29 | 1.54 | 260 | 1.30 | 1.15 | 1.47 | 775 | 1.37 | 1.28 | 1.47 |
| > = 60 | 716 | 1.25 | 1.16 | 1.35 | 415 | 1.32 | 1.20 | 1.46 | 1131 | 1.28 | 1.20 | 1.35 |
| All | 1802 | 1.41 | 1.35 | 1.48 | 1026 | 1.44 | 1.35 | 1.53 | 2828 | 1.42 | 1.37 | 1.48 |
Familial risks were adjusted for age, sex, time period, region of residence, socioeconomic status, and comorbidities.
Bold type: 95% CI does not include 1.00. O = observed number of cases with family history of kidney failure; SIR = standardized incidence ratio; CI = confidence interval.