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. 2014 Nov 25;9(11):e113308. doi: 10.1371/journal.pone.0113308

Figure 6. More open chromatin structure in mice fetuses with RA-induced spina bifida.

Figure 6

(A) The methylation level of H19 DMR1 is stable in RA-treated mice. For details, see the legend in Fig. 3. (B) and (F): The genomic profile of genes displayed in UCSC (mm9), the genomic locus of target regions in ChIP assay (black block in the gene schematic) (corresponding results shown in C and D or G and H), and the CpG island (green block underneath the gene schematic) (corresponding results shown in E and I) detected by MASSARRAY assay are shown. The number beside the block indicates the genomic location that was targeted. In the ChIP assay results (C and D or G and H), the enrichment in the y-axis represents the relative fold enrichment in which the higher enrichment in case or control is designated as 1. *: P<0.05; **: P<0.01; ***: P<0.0001 (Student's t-test). TSS: transcription start site.