TABLE 2:
Ion translocators implicated in cancer.
| Ion translocator protein | Species | References | Function |
|---|---|---|---|
| NaV1.5 sodium channel | Human | Onkal and Djamgoz (2009), House et al. (2010) | Oncogene |
| KCNK9 potassium channel | Mouse | Pei et al. (2003) | Oncogene |
| Ductin (proton V-ATPase component) | Mouse | Saito et al. (1998) | Oncogene |
| SLC5A8 sodium/butyrate transporter | Human | Gupta et al. (2006) | Oncogene |
| KCNE2 potassium channel | Mouse | Roepke et al. (2010) | Oncogene |
| KCNQ1 potassium channel | Human, mouse | Lee et al. (1997), Weksberg et al. (2001), Than et al. (2013) | Oncogene |
| SCN5A voltage-gated sodium channel | Human | House et al. (2010) | Oncogene |
| Metabotropic glutamate receptor | Mouse, human | Song et al. (2012), Speyer et al. (2012), Martino et al. (2013) | Oncogene |
| CFTR chloride channel | Human | Xie et al. (2013), Zhang et al. (2013) | Tumor suppressor |
| Connexin43 | Human | Sirnes et al. (2012) | Tumor suppressor |
| Acetylcholine receptor | Mouse | Felder et al. (1993) | Tumor suppressor |