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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: J Cell Physiol. 2015 Mar;230(3):595–602. doi: 10.1002/jcp.24777

Figure 7. Schematic showing the possible cross-talk between LTD4 and SCF in mast cells.

Figure 7

LTD4 alone induces calcium influx via CysLT1R leading to activation of c-fos and generation of inflammatory chemokine, MIP1β in MCs, while SCF alone enhances their proliferation through the activation of C-kit. However, simultaneous stimulation of MCs with both LTD4 and SCF synergistically enhance each other’s responses via cross-talk between associated signaling leading to augmented inflammatory and proliferatory responses.