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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Nat Genet. 2014 Nov 2;46(12):1363–1371. doi: 10.1038/ng.3138

Figure 5.

Figure 5

Tissue-Specific Tumor Networks. (a) MSM/N predictions of top 20 interactions gained and lost (green and yellow edges, respectively) in four tumor networks overlaid on the wild-type SH2-phosphosignaling network (gray edges, each representing an interaction with p > 0.85 probability, as in Supplementary Fig. 4), showing a bias for the “node” mode of perturbations. (b) Four tumor networks that show a bias for the “pathway” mode of perturbations. (c) Local neighborhoods of the PTEN network in different cancer tissue types. All networks were generated using a spring-electrical embedding in the Mathematica software package.