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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Chemistry. 2014 Oct 10;20(49):16174–16187. doi: 10.1002/chem.201404845

Figure 8.

Figure 8

Interaction of chromophores and the corresponding hybrid agents with G-quadruplex forming sequences (a) (10 μm), and new chromophore and platinum-chromophore hybrid agents. Circular dichroism (CD) spectra (b–d) of in the interaction between unfolded TEL24 (black dashed line) and increasing equivalents of a) A1, b) B1, and c) B2 to a final ratio of 5 equiv drug to one quadruplex (thick black line) (10 mm tetrabutylammonium phosphate/1 mm EDTA buffer, pH 6.75). CD spectra were also acquired of P1–A1 (red), P1–B1 (blue), and P1–B2 (green) incubated with pre-folded G-quadruplex-forming sequences (same buffer with 100 mm KCl added) for e) TEL24, f) NUC23A, g) NUC23P, and h) NUC25M. i) Induced circular dichroism (ICD) spectra for the chromophore region of P1–A1 (red), P1–B1 (blue), and P1–B2 (green) in complex with pre-folded TEL24. For representative structures of G4 topologies, see the Supporting Information.