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. 2014 Dec;62(12):879–888. doi: 10.1369/0022155414551367

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Figure 4. — Knockdown of p62 inhibits osteoclastogenesis and F-actin ring formation. (A) In RAW264.7 cells after transfection with p62 siRNA, the number of TRAP-positive multinuclear cells was significantly decreased as compared with the negative control (NC). (B) F-actin ring formation was inhibited in osteoclasts after transfection with p62 siRNA. (C) The mRNA expression levels of osteoclastogenesis-related genes were significantly decreased in RAW264.7 cells after knockdown of p62 as compared with the negative control (NC). mRNA expression was normalized against β-actin in the samples analyzed. The data represent the mean ± SEM from three different experiments performed in duplicate. *p<0.05; **p<0.01 versus the negative control. Scale, 50 µm.