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. 2014 Nov;33(11):539–544. doi: 10.5732/cjc.014.10175

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Chinese Journal of Cancer

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Figure 1. — miRNAs are processed through a complex series of highly regulated steps in the nucleus and the cytoplasm, from transcription through to their functional roles as transcript and protein level regulators. Abbreviations: RNA Pol II, RNA polymerase type II; pri-miRNA, primary microRNA; pre-miRNA, precursor microRNA; DGCR8, Drosha-DiGeorge syndrome critical region gene 8; XPO5, nuclear export factor exportin 5; RAN, ras-related nuclear protein; GTP, guanosine tri-phosphate; AGO, Argonaute; TRBP, TAR (HIV-1) RNA-binding protein 2; PACT, protein kinase, interferon-inducible double stranded RNA; Dicer, Dicer 1 ribonuclease Type III; miR*, passenger strand from mature miRNA duplex; miRISC, microRNA RNA-induced silencing complex; P-body, processing body.