|
AKT (v-akt murine thymoma viral oncogene homolog 1) |
Induces metastasis[60]
|
|
BCAT1 (branched chain amino acid transaminase 1, cytosolic) |
Induces cell proliferation, migration, and invasion[61]
|
|
BCL2 (B-cell CLL/lymphoma 2) |
Inhibits apoptosis[62]–[64]
|
|
CCND1 (cyclin D1) |
Promotes cell cycle G1-S transition through regulation of pRb[65]–[67]
|
|
DeltaNp63/TP73L [tumor protein p73-like, p63 splicing variants lacking NH(2)-terminal transactivating domain] |
Regulates Notch signaling, cell proliferation, and cell death[68]–[70]
|
|
EGFR (epidermal growth factor receptor) |
Regulates cell signaling[71]–[75]
|
|
EIF4E (eukaryotic translation initiation factor 4E) |
Promotes cell cycle progression by up-regulation of c-Myc and MMP9[76]
|
|
EVI1 (ecotropic viral integration site 1) |
Regulates chromatin remodeling[77]
|
|
FGF3/Int-2 (fibroblast growth factor 3) |
Promotes cell growth and tumor growth and invasion[78]
|
|
ERBB2 (v-erb-b2 erythroblastic leukemia viral oncogene homologue 2) |
Controls cell proliferation and angiogenesis[74],[79]
|
|
HRAS (Harvey rat sarcoma viral oncogene homolog) |
Induces cell cycle progression, regulates cell motility, and plays a role in cell signaling[72],[80],[81]
|
|
ID1 (inhibitor of DNA binding 1; dominant negative helix-loop-helix protein) |
Regulates cell growth and senescence[82]
|
|
IL8 (interleukin-8) |
Promotes metastasis through activation of epithelial-mesenchymal transition and Akt[83]
|
|
MACC1 (metastasis-associated in colon cancer 1) |
Induces cell proliferation, migration, invasion, and colony formation[84]
|
|
MDM2 (MDM2 oncogene, E3 ubiquitin protein ligase) |
Interacts with p53, to regulate its ability to control cell cycle and apoptosis[85],[86]
|
|
MET (Met proto-oncogene) |
Regulates cell proliferation and is involved in cancer signaling pathways[87],[88]
|
|
MYC (v-myc avian myelocytomatosis viral oncogene homologue) |
Regulates transcription of BMI1; induces cell proliferation, apoptosis, cell cycle progression; increases the radiotolerance of cancer cells[64],[78],[80],[89],[90]
|
|
PIK3CA (phosphoinositide 3-kinase, catalytic, alpha polypeptide) |
Activates the activities of critical downstream cell signaling partners and enhances invasion[72],[91]–[93]
|
|
SATB1 (special AT-rich-binding protein 1) |
Decreases cell proliferation and resistance to apoptosis[94]
|
|
SP1 (SP1 transcription factor) |
Regulates transcription of BMI1[89]
|
|
TNFAIP3 (tumor necrosis factor, alpha-induced protein 3) |
Inhibits apoptosis and negatively regulates inflammatory response[95]
|
