Figure 10.
Didactic diagram illustrating a hypothetical mechanism underlying dopaminergic modulation of tLTP induction in dentate granule cells. A glutamate and DA input onto a granule cell synapse is shown. Experimental manipulations that decrease (red arrows) or boost (green arrows) tLTP induction at the locations indicated are shown with abbreviations used in the text. D1-type receptor activity initiates a multistep pathway via MEK to diminish IA, which is mediated by the Kv4.2 potassium channel.