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. 2014 Nov 26;34(48):15962–15974. doi: 10.1523/JNEUROSCI.2526-14.2014

Figure 3.

Figure 3.

Futsch is neuroprotective in the context of TDP-43 overexpression. A, D42 Gal4 expression of TDP-43 WT or G298S results in impaired larval turning behavior, which is not significantly altered by futsch RNAi but is rescued by futsch OE. B, C, D42 Gal4 expression of TDP-43 variants, WT (B) and G298S (C), results in reduced adult survival time, which is rescued by futsch OE. FutschRNAi shifts the lethality caused by TDP-43 to pupal stage (see Results). The Student's t test was used to calculate larval turning time p values. The log-rank test was used to calculate survival p values. *p < 0.05; **p < 0.01; ***p < 0.001.