Table 5.
Human tissues and quantification of MAP1B in the cytoplasm of spinal cord motor neurons
| Case | Diagnosis | Age (years)/gender | PMT (hours) | Number of MNs counted | Percentage of MNs with MAP1B in cell body |
|---|---|---|---|---|---|
| C1 | Control brain–no pathology | 54/M | 6 | 148 | 0 |
| C2 | Subacute infarcts | 53/F | 4 | 162 | 1.8 |
| C3 | Metastatic carcinoma | 51/F | 5 | 65 | 0 |
| C4 | Metastatic carcinoma | 57/F | 11 | 28 | 0 |
| C5 | Pulmonary fibrosis | 57/M | 2 | 108 | 0 |
| C6 | Control brain–no pathology | 58/F | 5 | 62 | 0 |
| ALS1 | ALS | 62/F | 4 | 32 | 19 |
| ALS2 | ALS | 50/F | 7 | 10 | 30.0 |
| ALS3 | Familial ALS (C9ORF72) | 63/F | 4 | 35 | 0 |
| ALS4 | ALS | 60/F | 4 | 44 | 66 |
| ALS5 | ALS | 59/M | 4 | 121 | 72 |
| ALS6 | ALS | 63/F | 2 | 51 | 59 |
| ALS7 | ALS | 53/M | 8 | 25 | 52 |
| ALS8 | ALS | 55/M | 3 | 37 | 57 |
PMT, Postmortem interval; MN, motor neuron; M, male; F, female. The percentage of spinal cord motor neurons containing MAP1B in the cell body was determined in motor neurons observed in between two and four tissue sections per case. The average percentage of motor neurons containing MAP1B in the cell body was 0.3 ± 0.3% per control case and 44 ± 8.9% per ALS case (±SD).