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LDN affects expression of genes in the IL-6/STAT3 pathway. (A) LDN increased baseline IL-6 mRNA levels 4-fold compared with control mice not receiving the drug at baseline (P = 0.004). (B) LDN increased plasma IL-6 levels compared with control and augmented the rise in IL-6 in response to hepatectomy (t = 0, P = 0.04; t = 6, P = 0.009; t = 24, P = 0.0038). (C) LDN increased p-STAT3 compared with controls 24 hours after hepatectomy (P = 0.01). *P < 0.05; **P < 0.01.
