TABLE 1.

Flecainide concentrations for half inhibition of RyR2 (IC₅₀), Hill coefficients (H), open probability in the absence of flecainide (P_o max), and numbers of experiments (n) under various experimental conditions obtained from the dose-response curves in Fig. 1C. In each case, the luminal solution contained 250 mM Cs⁺, 100 μM Ca²⁺, and no Mg²⁺.

Symbol(Fig. 1, C and D)	Side ofFlecainide Addition	Cytoplasmic Ion Concentrations			IC50	H	Po max	n
		Cs+	Ca2+	Mg2+
		mM	μM	mM	μM
○	cis	250	100	0	87 ± 6	1.2 ± 0.2	0.97 ± 0.02	6
●	trans	250	100	0	250 ± 50	0.6 ± 0.2	0.91 ± 0.02	3
△	cis	250	100	1	25 ± 4	1.0 ± 0.3	0.75 ± 0.06	5
◇	cis	150	100	1	5.0 ± 1.0	1.4 ± 0.8	0.37 ± 0.10	4
⬜	cis	250	0.1	0	17 ± 2	2.0 ± 1.0	0.055 ± 0.038	8