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. 2014 Nov 26;4:339. doi: 10.3389/fonc.2014.00339

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Copyright © 2014 Royse, Zhi, Conner, Clodfelder-Miller, Srinivasasainagendra, Vaughan, Skibola, Crossman, Levy and Shrestha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The concentric circles represent an heatmap of −log10(p-value) values of pairwise comparison of the sample’s FPKM (A) normal to LGSIL and (B) LGSIL to HGSIL in each of six samples. At the periphery of the heatmap are the genes that report a significant −log10(p-value) value across at least two samples or more. The concentric heatmaps are ordered from outmost to innermost in the following sample ID order: 109, 110, 111, 113, 115, and 116. Each band in the concentric circle represents a gene and its color scheme corresponds the −log(p-value); RED bands are values over 1.3, GRAY bands have range between 0.05 and 1.3 and WHITE (merging with the background of the plot) represents ≤0.05.