Figure 2a.

Complement factor H with its C terminal which is surface regulatory end and N terminal which is complement component 3 (C3) regulatory end. Defects in C terminal leads to atypical hemolytic uremic syndrome while defects in N terminal leads to C3glomerulonephritis. (Factor I and factor H - Regulators of complement system, C3b - Fragments from breakdown of C3, iC3b - Inactive fragment from breakdown of C3b, factor P-Regulator of complement cascade stabilizes C3 convertase, Bb - Active subunit of CFB, FLUID - Fluid or circulatory phase, SURFACE - Cell surface phase, MAC - Membrane attack complex, C3 Reg - C3 regulatory or N terminal end of factor H, surface reg - Surface regulatory or C terminal end of factor H)