Figure 2c.

Animal model with complement factor I deficiency with accumulation of C3b, with a predilection for mesangium. (Factor I and factor H - Regulators of complement system, C3b - Fragments from breakdown of C3, iC3b-Inactive fragment from breakdown of C3b, factor P - Regulator of complement cascade stabilizes C3 convertase, Bb-Active subunit of CFB, FLUID-Fluid or circulatory phase, SURFACE-Cell surface phase, MAC - Membrane attack complex, C3 reg-C3 regulatory or N terminal end of factor H, surface reg-Surface regulatory or C terminal end of factor H)