Figure 2d.

Uncontrolled complement component 3 convertase activity leads predominantly to dense deposit disease while that of C5 convertase activity causes complement component 3 glomerulonephritis (C3GN). (DDD - Dense deposit disease, C3GN-C3 glomerulonephritis, factor I and factor H - Regulators of complement system, C3b - Fragments from breakdown of C3, iC3b - Inactive fragment from breakdown of C3b, factor P-Regulator of complement cascade stabilizes C3 convertase, Bb-Active subunit of CFB, FLUID - Fluid or circulatory phase, SURFACE-Cell surface phase, MAC - Membrane attack complex, C3 reg-C3 regulatory or N terminal end of factor H, surface reg - Surface regulatory or C terminal end of factor H)