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. 2014 Nov-Dec;24(6):339–348. doi: 10.4103/0971-4065.134089

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Copyright: © Indian Journal of Nephrology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pathological findings from a 53-year-old man with complement component 3 glomerulonephritis who presented with nephrotic range proteinuria, microscopic hematuria and renal failure. (a) Light microscopy shows accentuated lobularity and global glomerular hypercellularity (H and E) (b) Increased mesangial matrix with tram tracks in peripheral capillary loops (arrowheads) (c) Immunofluorescence showing strong granular capillary loop reactivity for complement component 3. (d) Electron microscopy with an endocapillary inflammatory cell (*), glomerular basement membrane duplication (arrowheads) and subendothelial electron-dense deposits (arrows)