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. 2014 Nov 26;8:140. doi: 10.3389/fncir.2014.00140

Figure 2.

Figure 2

Stimulation at 100 Hz in the MNTB revealed no effect of genotype on release properties in the LSO. To more stringently test for differences in release properties, we delivered 20 pulses at 100 Hz in tissue from WT (n = 8), het (n = 9), and KO (n = 8) mice. (A) Representative responses to 100 Hz trains of 20 pulses for WT (P4), het (P4), and KO (P4) tissue. (B) Example traces from (A), scaled for comparison. Traces were first scaled to force all genotypes to have the same value for first-response-amplitude; then, within each train, the baseline for each response was reset to zero (i.e., baseline for first-response). (C) First 5 responses from examples in (B), enlarged for clarity. (D,E) No differences were apparent between WT (n = 8), het (n = 9) and KO (n = 8) tissue for paired-pulse ratios (D; p = 0.75, see text) or cumulative event amplitudes (E; p = 0.28, see text). Probability of release, as estimated using these cumulative amplitude functions, was also similar among genotypes (see text).