Table 5.
Parameters used for the Quinidine PBPK model (Simcyp V12).
| Parameter | Value | Unit |
|---|---|---|
| Molecular weight | 324.4 | g/mol |
| LogP | 2.88 | |
| Compound type | Diprotic base | |
| pKa 1 | 4.2 | |
| pKa 2 | 8.8 | |
| Blood:plasma | 0.88 | |
| Fu plasma | 0.203 | |
| Main binding protein | albumin | |
| Absorption | First order absorption | |
| fa | 1 | |
| ka | 3 | 1/h |
| Distribution | Full PBPK model | |
| Vss | 1.16 | L/kg |
| Elimination | ||
| CLiv | 19.4 Caucasians 18.16 Chinese (Korean) |
L/h |
| CLR | 1.95 | L/h |
|
PD model |
Simple Emax model | |
| Emax | Parameter estimation used for fitting to clinical data | ms |
| EC50 |
Parameter estimation used for fitting to clinical data | μM |
| Baseline | 443 Korean 445 Caucasian |
ms |