Table 1.
STD | HFD | HFD + AICAR | |
---|---|---|---|
Body weight, g | 28.50 ± 0.64 | 45.30 ± 0.81* | 34.00 ± 1.23# |
Plasma glucose level, Mg/dl |
145.2 ± 5.1 | 187.0 ± 8.2* | 148.3 ± 10.2# |
Kidney weight, g | 0.306 ± 0.007 | 0.353 ± 0.006* | 0.318 ± 0.012# |
Kidney weight, g/mm of tibia length |
0.0154 ± 0.0007 | 0.0174 ± 0.0003* | 0.0159 ± 0.0004 |
Adiponectin, µg/ml | 14.6 ± 2.9 | 18.2 ± 2.3 | 25.7 ± 2.1*# |
Plasma insulin, ng/ml | 0.50 ± 0.01 | 1.07 ± 0.20* | 0.52 ± 0.03# |
UACR, µg/mg | 5.99 ± 1.40 | 79.80 ± 14.06* | 21.66 ± 4.46# |
Abbreviations: AICAR, 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; UACR, urine albumin/creatinine ratio.
Statistical analyses were performed by one-way analysis of variance (ANOVA) followed by Newman–Keuls,
P ≤ 0.05 versus mice on STD and
P ≤ 0.05 versus mice on HFD.
Values are means ± s.e.m; n = 6 in each group.