Figure 13.

(1) Justification on probable relationship between structural features of POR (brittle gelling properties) and better drug release rate profile (improvement strategies such as CS blend) caused by improving the gel strength (by CS-POR blend), to improve the effectiveness of whole formulation against fungal strains [15–17]. (2) Role of alkaline treatment in conversion of high to low mol. wt. sulphated polysaccharide (with conversion of L-galactose 6-sulfate residue to 3,6 anhydro form) which improves the gelling strength followed by the release rate profile of matrix [15–17].