(b).

Incubation temp.	1 h 0°C
Solution spiked	Vehicle	Low	Med	High
Final MDCO-216 concentration (μg/mL protein):	0	100	300	1000
		Prebeta-1 HDL net due to plasma*
Spiked in plasma 1	62	75	101	105
Spiked in plasma 2	126	126	131	121
Spiked in plasma 3	112	144	143	125
Spiked in plasma average	100	115	125	117
% of plasma spiked with vehicle**		115%	125%	117%
Incubation temp.	1 h 37°C
Solution spiked	Vehicle	Low	Med	High
*Final MDCO-216 concentration (μg/mL protein):	0	100	300	1000
		Prebeta-1 HDL net due to plasma*
Spiked in plasma 1	5	77	162	379
Spiked in plasma 2	12	89	153	375
Spiked in plasma 3	23	127	173	401
Spiked in plasma average	13	98	163	385
% of plasma spiked with vehicle**		733%	1220%	2888%

^*Value for MDCO-216 spiked in plasma minus value for MDCO-216 spiked in Vehicle (Table 1(a)) in μg/mL. ^**(value for plasma plus MDCO-216 minus value for MDCO-216 in vehicle)/value for plasma spiked with vehicle.