Table 2.
Worst acute and delayed rectal toxicity in patients treated to 50 Gy dose in phase I and phase II studies.
| Rectal toxicity | All patients (n = 91) |
50 Gy phase I (n = 14) |
50 Gy phase II (n = 47) |
|||
|---|---|---|---|---|---|---|
| Grade | Acute No. (%) | Late No. (%) | Acute No. (%) | Late No. (%) | Acute No. (%) | Late No. (%) |
| 0 | 39 (42.9) | 38 (41.8) | 5 (35.7) | 5 (35.7) | 18 (38.3) | 15 (32) |
| 1 | 33 (36.3) | 27 (29.7) | 7 (50) | 6 (43) | 16 (34) | 15 (32) |
| 2 | 17 (18.7) | 21 (23.1) | 2 (14.3) | 2 (14.3) | 11 (23.4) | 13 (27.7) |
| 3 | 1a (1.1) | 3 (3.3) | 0 (0) | 0 (0) | 1a (2.1) | 3 (6.4) |
| 4 | 1 (1.1) | 2 (2.2) | 0 (0) | 1 (7.1) | 1 (2.1) | 1 (2.1) |
| Number of patients w/grade 3+ toxicity | 6 (6.6%) | 1 (7.1%) | 5 (10.6%) | |||
aFor this patient, toxicity occurred on day 225 (acute period), but persisted to day 470, well into the delayed toxicity time period. Therefore, this patient was reported as having high grade acute and delayed toxicity. While seven total toxicities are reported, this occurred in a total of six patients.