Figure 7.
Frataxin-deficient YG8 hemizygote mouse cerebellum shows increased inducibility of inflammation with LPS treatment compared with WT. (A) Immunohistochemistry of frataxin-deficient YG8 hemizygote and WT cerebellar section with antibody specific to Iba1. The LPS treatment has increased the protein concentration of Iba1 in mutants 1.37-fold compared with WT which increased 1.16-fold from similar baseline expression in the PBS treatment. (B) Quantification of immunohistochemistry. Bars represent averages ± standard deviations (n = 4, P < 0.05*, P < 0.005**).