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. 2014 Nov 26;9(11):e113048. doi: 10.1371/journal.pone.0113048

Table 1. Characteristics of Studies Included in the Meta-analysis.

Author/year Design/duration Participa-ntsNo. Population relative risk(95% CI) Covariates
Gottlieb/1998 [23] Retrospective cohort/two years 41814 age 73.3±8.8, COPD subjects with previous history of myocardial infarction Mortality (0.60, 0.57–0.63) Unadjusted
Chen/2001 [24] Retrospective cohort/one year 10988 age<65, COPD or asthma subjects with previous history myocardial infarction Mortality (0.86, 0.73–1.00) Age, sex, comorbidities, CAD, cardiovascular drugs, physician speciality
Sin/2002 [25] Retrospective cohort/median 21 months 3834 age 79±8, COPD subjects with heart failure Mortality (0.78, 0.63–0.95) Age, sex, comorbidities, cardiovasculardrugs, physician speciality
taszewsky/2007 [27] Retrospective cohort/median 23 months 628 age 67±9, COPD subjects with heart failure Mortality (0.55, 0.37–0.82) Unadjusted
Au/2004 [26] Retrospective cohort/two years 1966 age 68.1±9.9, Veteran Affairs COPD subjects with hypertension Mortality (0.56, 0.16–1.93);ECOPD (0.65, 0.29–1.48) Comorbidity, age, history of COPD, bronchodilators, smoking, coronary artery disease, diabetes
Dransfield/2007 [29] Retrospective cohort/− 825 age 68±11, COPD subjects with acute Exacerbation Mortality (0.39, 0.14–0.99);ECOPD (0.46, 0.21–1.04) Age, CHD, CHF, liver disease, COPD exacerbations, malignancy, smoking, FEV1
Van Gestel/2008 [28] Retrospective cohort/median 5 years 1205 COPD subjects with vascular disease Mortality (0.73, 0.60–0.88) Age, sex, hypertension, hypercho- lesterolemia, diabetes, renal func- tion, smoking, BMI, CAD, FEV1, cardiovascular drugs
Hawkins/2009 [30] Retrospective cohort/median 25 months 1258 age 68.1±9.9, COPD subjectswith myocardial infarction Mortality (0.74, 0.68–0.80) Unadjusted
Olenchock/2009 [31] Retrospective cohort/two years 12967 COPD or asthma subjects withacute coronary syn- dromes Mortality (0.52,0.45–0.60). Unadjusted
Rutten/2010 [32] Retrospective cohort/7.2 years 2230 Age 64.8±11.2, COPD primary care Mortality(0.68,0.56–0.83) for Cardio-selective BB,(0.82,0.61–1.10) fornon- selective BB; ECOPD(0.71, 0.60–0.83). Age, sex, diabetes, hypertension, CAD, CVD drugs, pulmonary drugs
Short/2011 [33] Retrospective cohort/mean 4.35 years 5977 Mean age 69.1 years, COPD primary care Mortality(0.78,0.67–0.92);ECOPD (0.39, 0.32–0.48). CAD and Respiratory disease, age, sex, diabetes, smoking, FEV1, cardiovascular drugs
tefan/2012 [35] Retrospective cohort/two years 35082 Age 73(65–80), COPD with heart failure, hypertension, ischemic heart disease In hospital mortality (0.88, 0.71–1.09); ECOPD(0.98, 0.77–1.24). Age, sex, underlying cardiovascular condition, ischaemic heart disease, congestive heart failure, drug, et al.
Ekström/2013 [37] Prospective cohort/4 years 2249 age>49, Severe COPD mortality (1.19, 1.04–1.37). Age, sex, body mass index, world heath organization performance status, resting blood gas tensions breathing air,comorbidities, and concomitant medication
geloni/2013 [34] Retrospective cohort/median 36 months 208 COPD after coronary artery bypass grafting Mortality (0.38, 0.20–0.71);ECOPD (1.02, 0.046–22.5). Unadjusted
Mentz/2013 [36] Retrospective cohort/60–90 days 725 age 73(63–80), COPD with heart failure Mortality (0.89, 0.59–1.35) Unadjusted