Figure 4. Effect of sub-chronic oral administration of vehicle and D-473 on the duration of immobility in the forced swimming test in rats.

One way ANOVA analysis demonstrates significant effect among treatments: F (4, 24) = 10.33 (P<0.0001). Dunnett’s analysis showed that the effect of D-473 at three doses (10, 25 and 50 mg/kg) on immobility was statistically significant different compared to vehicle (P<0.01).