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. 2014 Sep 8;9(11):2621–2631. doi: 10.1021/cb5003224

Figure 2.

Figure 2

DMS footprinting of 23S rRNA. Dideoxy sequencing lanes G, C, A, and T (lanes 1–4) followed by unmodified rRNA (lane 5), DMS modified 23S rRNA (lane 6), DMS modified 23S rRNA in the presence of clarithromycin and 7b intermediate (lanes 7–8, respectively), 23S rRNA DMS modified in the presence of 12a–h (lanes 9–16, respectively). A representative complete gel is shown in SI Figure S2.