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. 2014 Sep 8;9(11):2621–2631. doi: 10.1021/cb5003224

Scheme 2. Synthesis of Peptolides 12ah.

Scheme 2

Reagents and conditions: (a) 7a or 7b, CuI, THF, diisopropylethylamine (DIPEA), room temperature; (b) TFA/TIPS/phenol, room temperature. The structures of deprotected alkyne peptide 1316 are in the Supporting Information (SI), Figure S1.