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. 2014 Oct 10;54(11):3080–3090. doi: 10.1021/ci500437r

Figure 1.

Figure 1

Effect of compound 34 on the replication of HIV-189BZ167 and the viability of primary human PBMCs. Black squares show the effect of compound 34 on the infection of primary human PBMCs by the clade B primary isolate HIV-189BZ167. Virus infection is expressed as the percentage of infection (measured by reverse transcriptase activity) observed in the presence of compound relative to the level of infection observed in the absence of the compound. The data from three replicates are shown. Red circles show the effect of the compound on the viability of the PBMCs and demonstrate that compound 34 is not toxic up to the highest concentration tested (100 μM). The IC50 value for compound 34 against HIV-189BZ167 = 14.2 ± 1.7 μM.