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. 2014 Nov 26;9(11):e113598. doi: 10.1371/journal.pone.0113598

Figure 2. The effects of sildenafil citrate on CM-induced renal dysfunction.

Figure 2

Serum samples were prepared from whole blood collected at various time points. Creatinine concentrations were determined using a Luminex xMap assay. (A) Time course of serum creatinine concentration in animals treated with increasing concentrations of CM. (B) Time course of serum creatinine concentration in animals pretreated with sildenafil citrate (6.0 mg/kg; single dose or q8 h) prior to CM exposure (5.0 g I/kg). (C) Maximum serum creatinine concentration in animals treated with increasing concentrations of CM. (D) Maximum serum creatinine concentration in animals pretreated with sildenafil citrate (6.0 mg/kg; single dose or q8 h) prior to CM exposure (5.0 g I/kg). Values are presented as mean ± SEM; n = 3–5. * indicates p<0.05 vs. 2.5 g I/kg and † indicates p<0.05 versus 5.0 g I/kg by one-way ANOVA and Dunnett's multiple comparisons test.