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. 2014 Nov 26;9(11):e113598. doi: 10.1371/journal.pone.0113598

Figure 4. Representative histological lesions in kidneys from rabbits subjected to CIAKI.

Figure 4

Renal cortex from rabbits treated with (A) 2.5 g I/kg CM, (B) 10.0 g I/kg CM, or (C) 5.0 g I/kg CM and sildenafil citrate (6.0 mg/kg, q8 h). In a rabbit treated with 2.5 g I/kg there were no histological alterations in the cortex. (A, summary pathology score  = 0) In a rabbit treated with 10.0 g I/kg there was severe tubular necrosis (arrows) affecting >50% of the cortical tubules. (B, summary pathology score  = 7). In a rabbit treated with 5.0 g I/kg CM and sildenafil citrate there was tubular necrosis affecting a much smaller percentage of cortical tubules (C, summary pathology score  = 3). Higher magnification of tubular necrosis from a rabbit in the 10.0 g I/kg group shows details of tubular necrosis, (arrows) evidenced by loss of cellular detail in the tubules, nuclear loss or condensation, and sloughing of necrotic cell debris into the tubule lumen. (D). A similar area in a rabbit treated with 2.5 g I/kg CM shows no alterations in the tubules (E). Hematoxylin and eosin stain. Original magnifications for A, B, C = ×200; bars  = 100 µm; for D, E  = ×600, bar  = 20 µm.