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. 2014 Nov 26;9(11):e113689. doi: 10.1371/journal.pone.0113689

Figure 1. Lack of effect of SC-51089 on brain pathology and NDS after CCI in WT mice.

Figure 1

(A) NDS 24 and 48 h assessed for CCI-injured WT mice following vehicle or SC-51089 treatment. (B) Representative cresyl violet-stained brain sections from animals of the same groups assessed 48 h after experimental injury. (C and D) Stereological quantification of the cortical lesion volume (C) and hippocampal edema in the ipsilateral hemisphere expressed as the averaged relative hippocampal area between bregma 1 and 2 normalized to respective values measured on the contralateral side (D) in vehicle and SC-51089-treated animals 48 h after CCI. The “ns” denotes not statistically significant (P>0.05, Mann-Whitney rank sum test), P values in C and D obtained from Student’s t-test, n = 6–9 per group.