Table 3.
Diagnostic performance for entropy and uniformity with or without filtrations in assessing synchronous colorectal liver metastasis by receiver operating characteristics (ROC) curve analyses
| AUC | Sensitivity | Specificity | PPV | NPV | Cutoff | |
|---|---|---|---|---|---|---|
| Mean grey-level intensity | ||||||
| No filtration | 0.59 | 0.40 (4/10) | 0.87 (13/15) | 0.67 (4/6) | 0.68 (13/19) | >118.98 |
| 95% CI | 0.37–0.78 | 0.14–0.73 | 0.58–0.98 | 0.24–0.94 | 0.43–0.86 | |
| σ = 0.5 | 0.54 | 1 (10/10) | 0.2 (3/15) | 0.45 (10/22) | 0.1 (3/3) | ≤0.16 |
| 95% CI | 0.33–0.74 | 0.66–1 | 0.05–0.48 | 0.25–0.67 | 0.30–1 | |
| σ = 1.5 | 0.56 | 0.3 (3/10) | 0.93 (14/15) | 0.75 (3/4) | 0.67 (14/21) | ≤0.34 |
| 95% CI | 0.35–0.75 | 0.08–0.65 | 0.66–1 | 0.22–0.99 | 0.43–0.85 | |
| σ = 2.5 | 0.54 | 0.5 (5/10) | 0.67 (10/15) | 0.5 (5/10) | 0.67 (10/15) | ≤1.45 |
| 95% CI | 0.33–0.74 | 0.2–0.8 | 0.39–0.87 | 0.2–0.8 | 0.39–0.87 | |
| Entropy | ||||||
| No filtration | 0.61 | 0.4 (4/10) | 1 (15/15) | 1 (4/4) | 0.71 (15/21) | >6.64 |
| 95% CI | 0.40–0.80 | 0.14–0.73 | 0.75–1 | 0.4–1 | 0.48–0.88 | |
| σ = 0.5 | 0.55 | 0.2 (2/10) | 1 (15/15) | 1 (2/2) | 0.65 (15/23) | >8.43 |
| 95% CI | 0.34–0.75 | 0.04–0.56 | 0.75–1 | 0.20–1 | 0.43–0.83 | |
| σ = 1.5 | 0.74 | 64 (9/14) | 91 (10/11) | 90 (9/10) | 67 (10/15) | ≥7.66 |
| 95% CI | 0.53–0.94 | 36–86 | 57–100 | 54–99 | 39–87 | |
| σ = 2.5 | 0.78 | 78 (7/9) | 81 (13/16) | 70 (7/10) | 87 (13/15) | ≥7.08 |
| 95% CI | 0.57–0.99 | 40–96 | 54–95 | 35–92 | 58–98 | |
| Uniformity | ||||||
| No filtration | 0.60 | 0.5 (5/10) | 0.87 (13/15) | 0.71 (5/7) | 0.72 (13/18) | ≤12.08 × 10−3 |
| 95% CI | 0.39–0.79 | 0.20–0.80 | 0.58–0.98 | 0.30–0.95 | 0.46–0.89 | |
| σ = 0.5 | 0.55 | 0.5 (5/10) | 0.73 (11/15) | 0.56 (5/9) | 0.69 (11/16) | ≤3.98 × 10−3 |
| 95% CI | 0.34–0.75 | 0.2–0.8 | 0.45–91 | 0.23–0.85 | 0.41–0.88 | |
| σ = 1.5 | 0.73 | 62 (8/13) | 83 (10/12) | 80 (8/10) | 67 (10/15) | ≤5.91 × 10−3 |
| 95% CI | 0.52–0.93 | 32–85 | 51–97 | 44–96 | 39–87 | |
| σ = 2.5 | 0.77 | 70 (7/10) | 80 (12/15) | 70 (7/10) | 80 (12/15) | ≤9.08 × 10−3 |
| 95% CI | 0.57–0.97 | 35–92 | 51–95 | 35–92 | 51–95 | |
Data are percentages; absolute numbers are given in parentheses. AUC: area under the ROC curve; PPV: positive predictive value; NPV: negative predictive value; CI: confidence interval.