Table 2.

Diagnostic Test Characteristics of 2D-MRE in the Detection of Advanced Fibrosis as Well as Other Secondary Outcomes

	N Positive	N Negative	AUC	Cutoff (Kpa)	Raw Sensitivity	Raw Specificity	Raw PPV	Raw NPV	CV Sensitivity	CV Specificity	CV PPV	CV NPV
Primary
Stage 0, 1, 2 vs. 3, 4	22	95	0.924	3.64	0.864	0.905	0.679	0.966	0.818	0.895	0.643	0.955
Secondary
Stage 0 vs. 1, 2, 3, 4	74	43	0.838	3.02	0.554	0.907	0.911	0.542	0.446	0.907	0.892	0.488
Stage 0, 1 vs. 2, 3, 4	35	82	0.856	3.58	0.657	0.915	0.767	0.862	0.629	0.915	0.759	0.852
Stage 0, 1, 2, 3 vs. 4	10	107	0.894	4.67	0.8	0.944	0.571	0.981	0.7	0.925	0.467	0.971
No NASH vs. NASH	91	26	0.733	3.26	0.42	0.923	0.951	0.316	0.429	0.885	0.929	0.307
Multivariable-adjusted stage 0, 1, 2 vs. 3, 4	22	95	0.952	3.64	0.864	0.905	0.679	0.966	0.818	0.905	0.667	0.956

Multivariable-adjusted model includes age and sex adjustment.

Abbreviations: N, number of patients; AUC, area under the curve; CV, cross-validated.