Table 2.
Selected Gene Ontology categories of biological processes significantly enriched with differentially expressed genes in black bear skeletal muscle based on the data from two microarrays (Fedorov etal. 2009; this study). Arrows indicate direction of gene expression changes in hibernating animals. FDR is false discovery rate and NES is normalized enrichment score.
| GO Miner | GSEA | |||||
|---|---|---|---|---|---|---|
| GO Category | Total genes on array |
Changed genes |
|
|||
| Enrich- ment |
FDR | NES | FDR | |||
| Translation (GO: 0006412) | 365 | 47↑ | 2.999 | <0.001 | 1.59 | 0.037 |
| Ribosome biogenesis (GO: 0042254) |
134 | 16↑ | 2.781 | 0.006 | 1.54 | 0.035 |
| Glucose metabolic process (GO: 0006006) |
131 | 18↓ | 2.579 | 0.030 | −1.41 | 0.076 |
| Oxidation reduction (GO: 0055114) |
610 | 59↓ | 1.815 | 0.003 | −1.66 | <0.001 |