Table 3.
Gene Ontology categories of biological processes significantly enriched with differentially expressed genes in the arctic ground squirrel skeletal muscle. Arrows indicate direction of gene expression changes in torpid animals. FDR is false discovery rate.
| GO Miner | GSEA | |||||
|---|---|---|---|---|---|---|
| GO Category | Total genes on array |
Changed genes |
|
|||
| Enrich- ment |
FDR | NES | FDR | |||
| Translation (GO:0006412) |
343 | 581↑ | 2.548 | <0.001 | 1.81 | 0.006 |
| Ribosome biogenesis (GO:0042254) |
142 | 34↑ | 3.608 | <0.001 | 1.98 | <0.001 |
| Oxidation reduction (GO:0055114) |
589 | 59↓ | 2.657 | <0.001 | −1.24 | 0.123 |
| Glucose metabolic process (GO: 0006006) |
125 | 29↓ | 6.154 | <0.001 | −1.76 | 0.006 |
| Glucose catabolic process (GO:0006007) |
54 | 18↑ | 8.842 | <0.001 | −1.94 | <0.001 |
| Gluconeogenesis (GO:0006094) |
38 | 13↓ | 9.075 | <0.001 | −1.89 | 0.012 |
| Alcohol catabolic process (GO:0046164) |
64 | 19↓ | 7.875 | <0.001 | −1.31 | 0.133 |
| Pyruvate metabolic process (GO:0006090) |
52 | 15↓ | 7.652 | <0.001 | −1.69 | 0.009 |
| Cellular respiration (GO:0045333) |
141 | 16↓ | 3.010 | 0.002 | −1.55 | 0.063 |