Table 1. Demographics, Psychosomatic Scores and Quantitative Measurements of the Three Groups of Participants.
Kruskal Wallis test was used to assess the associations of quantitative traits in the three groups.
| Data: mean ± SEM | IBS-C | Healthy Controls | IBS-D | p value |
|---|---|---|---|---|
| N | 30 | 30 | 64 | |
| Gender (F/M) | 30/0 | 22/8 | 59/5 | |
| Age, y | 44.6 ± 1.1 | 39.3 ± 2.1 | 41.9 ± 1.5 | 0.161 |
| BMI, kg/m2 | 26.6 ± 0.8 | 25.4 ± 0.7 | 29.7 ± 0.9 | 0.013 |
| Anxiety score (HAD) | 2.8 ± 0.5 | 2.1 ± 0.3 | 4.0 ± 0.5 | 0.117 |
| Depression score (HAD) | 0.9 ± 0.2 | 0.4 ± 0.1 | 1.6 ± 0.2 | 0.0005 |
| Psychosomatic symptom score | 0.4 ± 0.06 | 0.2 ± 0.04 | 0.5 ± 0.04 | <0.0001 |
| Bowel function | ||||
| # BM/day | 0.85± 0.1 | 1.18 ± 0.1 | 2.26 ± 0.1 | <0.0001 |
| BM form | 2.86 ± 0.2 | 3.77 ± 0.1 | 4.76 ± 0.1 | <0.0001 |
| Quantitative traits | ||||
| Fecal fat (g/day) | 5.1 ± 0.9 | 6.6 ± 0.8 | 9.1 ± 0.9 | 0.007 |
| Serum C4 (ng/mL) | 23.5± 4.4 | 25.3± 3.1 | 34.7± 3.6 | 0.019 |
| Serum FGF-19 (pg/mL) | 134.9 ± 18.4 | 171.6 ± 25.0 | 118.8 ± 10.8 | 0.051 |
| Total Fecal Bile Acid (μM/48h) | 579 ± 161 | 957 ± 185 | 2495 ± 382 | <0.0001 |
| Mean % fecal LCA/CDCA/DCA/CA | 49/1/48/2 | 39/1/59/1 | 30/6/53/8 | All <0.001, except DCA =0.033 |
| Gastric emptying T1/2 min | 117.3 ± 5.0 | 120.0 ± 5.7 | 124.7 ± 3.8 | 0.51 |
| Colonic filling at 6 h, % | 55.0 ± 5.5 | 54.1 ± 4.3 | 55.2 ± 3.4 | 0.92 |
| Colonic transit GC24 | 2.34± 0.2 | 2.41 ± 0.2 | 2.85 ± 0.2 | 0.13 |
| Colonic transit GC48 | 3.22± 0.17 | 3.86± 0.17 | 4.18± 0.12 | 0.0001 |
| Urine mannitol 0–2h | 264.8 ± 42.9 | 355.2 ± 49.5 | 444.3 ± 75.2 | 0.039 |
| Urine mannitol 8–24h | 65.8 ± 16.1 | 43.6 ± 4.2 | 45.5 ± 5.0 | 0.708 |
BM=bowel movements; LCA=lithocholic acid; CDCA=chenodeoxycholic acid; DCA=deoxycholic acid; CA=cholic acid; ns=not significant