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. 2014 Aug 21;15(6):1598–1602. doi: 10.1208/s12249-014-0189-5

Table III.

Pharmacokinetic Parameters Following Intravenous and Intranasal Administration of OZ Formulations to Rabbits (n = 3)

Parameter i.v. solution i.n. OZ-CS NP i.n. OZ solution
K e(min−1) 0.007 ± 0.002 0.007 ± 0.001 0.005 ± 0.002
C max (ng/mL) 364.22 ± 163.19 197.00 ± 75.19 84.04 ± 44.38
T max (min) 5 20 20
T 1/2 (min) 101.46 ± 33.07 109.0 ± 20.02 160.53.0 ± 51.96

K e K elimination, T 1/2 half-life, T max peak time, C max peak concentration, i.v. intravenous, i.n. intranasal, OZ-CS olanzapine-chitosan, NP nanoparticle