Table IV.
In Vitro Aerosolization Performance with Capsules1.2 in Aerolizer at 90 L/min. Emitted Fraction (EF), Fine Particle Fraction (FPF), Respiratory Fraction (RF), Mass Median Aerodynamic Diameter (MMAD), and Geometric Standard Deviation (GSD) Obtained from Formulations Containing SBS Blended with Granulated Lactose Carriers GL 212–250 μm, GL 250–300 μm, GL 300–425 μm, GL 425–600 μm, GL 600–850 μm, and GL 850–1,000 μm (Mean ± SD, n = 3)
| GL 212–250 μm | GL 250–300 μm | GL 300–425 μm | GL 425–600 μm | GL 600–850 μm | GL 850–1,000 μm | |
|---|---|---|---|---|---|---|
| EF (%) | 89.0 (1.7) | 89.2 (0.8) | 89.1 (1.4) | 90.0 (1.2) | 88.9 (2.1) | 84.6 (3.8) |
| FPF (%) | 37.1 (4.5) | 38.2 (6.1) | 34.9 (3.3) | 30.7 (2.6) | 31.2 (2.9) | 37.8*(4.2) |
| RF (%) | 33.0 (4.3) | 34.1 (5.2) | 31.1 (2.8) | 27.6 (2.6) | 27.7 (2.6) | 32.0 (4.5) |
| MMAD (μm) | 1.73 (0.02) | 1.68 (0.04) | 1.70 (0.06) | 1.60 (0.04) | 1.62 (0.07) | 1.64 (0.06) |
| GSD | 1.7 (0.0) | 1.7 (0.0) | 1.7 (0.1) | 1.7 (0.0) | 1.8 (0.0) | 1.8 (0.1) |
*P < 0.05