Table II.

Nucleation (k ₁) and Growth (k ₂) Rate Constants of Aggregation of IFNβ-1b in the Presence of Different Concentrations of Arginine. Calculations by the Best Fit of Experimental Data to Eq. 1. R ² > 0.98 and χ ² < 0.0005

	k 1 (min−1)	k 2 (M−1 min−1)
Control	3.9 ± 1.1 × 10−4	2.4 ± 0.6 × 10−7
Arginine 50 mM	1.2 ± 0.2 × 10−5	7.8 ± 0.4 × 10−7
Arginine 150 mM	1.0 ± 0.1 × 10−5	8.0 ± 0.2 × 10−7
Arginine 200 mM	5.2 ± 0.4 × 10−6	4.8 ± 0.5 × 10−7
Arginine 500 mM	3.6 ± 0.3 × 10−6	5.0 ± 0.4 × 10−7

Mean ± SD, with two replicates