Table III.

Pharmacokinetic Parameters of FEN After Oral Administration of FEN Suspension and FEN-NLC to Rats

Parameters	FEN suspensiona	FEN-NLC
C max (μg/mL)	5.38 ± 0.45	21.72 ± 2.53*
T max (h)	2.8 ± 0.5	2.0 ± 0.0
t 1/2 (h)	10.4 ± 2.9	30.96 ± 7.29
K el (h−1)	0.056 ± 0.018	0.023 ± 0.005
AUC0-∞ (h.μg/mL)	97.10 ± 18.82	400.03 ± 93.15*

Each value represents the mean ± S.D. (n = 6)

^aModified from reference (1)

*p < 0.05, compared with the drug suspension