Table III.

In Vitro Aerosol Performance Using the Next Generation Impactor™ for Co-spray-dried (co-SD) Aerosol Systems Including Mass Median Aerodynamic Diameter (MMAD), Geometric Standard Deviation (GSD), Fine Particle Fraction (FPF), Respirable Fraction (RF), and Emitted Dose (ED). (n = 3, ave ± SD)

Co-SD system composition (molar ratio)	MMAD (μm)	GSD (μm)	FPF (%)	RF (%)	ED (%)
0PTX:100DPPC/DPPG	10.4 ± 1.3	4.5 ± 1.0	35.8 ± 3.9	53.6 ± 1.7	80.0 ± 6.7
25PTX:75DPPC/DPPG	3.3 ± 0.5	2.2 ± 0.6	81.6 ± 8.8	51.3 ± 6.1	82.0 ± 6.6
50PTX:50DPPC/DPPG	1.9 ± 0.1	1.9 ± 0.1	86.7 ± 2.6	63.8 ± 0.1	81.6 ± 8.2
75PTX:25DPPC/DPPG	2.3 ± 0.2	2.1 ± 0.4	77.6 ± 2.4	58.2 ± 1.2	90.7 ± 7.1

PTX paclitaxel, DPPC dipalmitoylphosphatidylcholine, DPPG dipalmitoylphosphatidylglycerol