Table II.
Characterization of Mixed Nanomicellar Formulation
| Formulation code/number | Absorbance at 400 nm ± S.D | D.T (°C) ± S.D | R.T (sec) ± S.D | Osmolality (mOsm/kg) | Viscosity (cP) | Zeta potential (mV) | |
|---|---|---|---|---|---|---|---|
| Before | After | ||||||
| F1 | 0.040 ± 0.001 | A.D.T | N.D | 205 | 299 | 1.79 | −2.26 |
| F2 | 0.013 ± 0.002 | 83.9 ± 0.87 | 9.0 ± 1.00 | 218 | 307 | 1.68 | −1.67 |
| F3 | 0.020 ± 0.001 | 76.3 ± 1.49 | 40.0 ± 1.70 | 219 | 315 | 1.72 | −2.92 |
| F4 | 0.046 ± 0.001 | 92.5 ± 0.87 | 16.0 ± 2.31 | 253 | 289 | 1.59 | −1.63 |
| F5 | 0.025 ± 0.001 | 76.2 ± 0.76 | 28.0 ± 1.73 | 203 | 315 | 1.74 | −1.32 |
| F6 | 0.044 ± 0.001 | 73.5 ± 0.87 | 42.0 ± 12.0 | 222 | 308 | 1.65 | −2.30 |
| F7 | 0.046 ± 0.001 | 71.3 ± 0.81 | 18.0 ± 2.31 | 201 | 295 | 1.69 | −3.41 |
| F8 | 0.044 ± 0.001 | 91.2 ± 0.30 | 15.0 ± 1.00 | 214 | 301 | 1.75 | −2.47 |
| F9 | 0.025 ± 0.001 | 71.0 ± 0.79 | 40.0 ± 5.00 | 216 | 298 | N.D | −1.89 |
In osmolality columns “before” means before addition of tonicity enhancing agent and “after” means improved tonicity after addition of tonicity enhancer
D.T dissociation temperature, R.T regeneration time, mOsm/kg milliOsmols/kilogram, cP centipoise, mV millivolts, A.D.T. above detection point (>100°C), N.D not determined