Fig. 2.

RRs of achieving NEDA status for fingolimod, DMF and teriflunomide versus placebo. Estimated RRs for the pooled FREEDOMS population, pooled DEFINE and CONFIRM population, and TEMSO populations are shown as solid lines as indicated (estimated). Dashed lines represent the predicted RRs for fingolimod versus placebo in alternative trial populations using the final models (predicted). An RR above 1.0 indicates an improved outcome for treatment relative to placebo. CONFIRM comparator and an oral fumarate in relapsing–remitting multiple sclerosis, DEFINE determination of the efficacy and safety of oral fumarate in relapsing–remitting multiple sclerosis, DMF dimethyl fumarate, FREEDOMS FTY720 research evaluating effects of daily oral therapy in multiple sclerosis, MRI magnetic resonance imaging, NEDA no evidence of disease activity, RR relative risk, TEMSO teriflunomide multiple sclerosis oral