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Secretion of soluble factors from MSCs cultured in 2D or 3D substrates.
| IL-6 | PGE2 | TSG-6 | MCP-1 | VEGF | M-CSF | RANKL | |
|---|---|---|---|---|---|---|---|
| 2D MSCs | 57.4 ± 14.9 | 6.0 ± 2.2 | 4.3 ± 1.6 | 27.8 ± 8.8 | 39.3 ± 10.7 | 3.8 ± 0.6 | 1.2 ± 0.1 |
| 3D MSCs | 34.1 ± 8.9* | 14.7 ± 6.1* | 9.8 ± 2.0* | 10.3 ± 2.9* | 27.0 ± 6.6 | 4.3 ± 1.3 | 0.6 ± 0.1* |
The data are expressed as pg/ml.μg of total proteins. Each value represents the mean ± SD of five independent experiments. *p < 0.05 compared to 2D MSCs.
